The study here will provide you with the most updated information about joint supplements which aim to reduce pain and inflammation and restore flexibility and mobility.
The Best Joint Supplements of the Year

Unfortunately, our joints don’t stay in top condition forever. As we age, they lose fluids in between the joints, and this causes stiffness and a loss of flexibility. Ligaments can also get shorter, which can also lessen your flexibility (source).
In addition, our cartilage can degenerate with age, and sometimes it rubs together and wears down further. This causes pain in the joints as well as inflammation (source).
Joint pain is the result of the stiff or worn cartilage connecting two or more bones together. The stiffness coupled with inflammation triggers joint pain.
Dealing with the symptoms of arthritis is a day-to-day battle for many people, as they struggle to do some of the simple things they need to accomplish. One possible option is to begin taking an organic joint supplement.
Our Recommended Best Joint Pain Supplements

Premium Joint Support: ProJoint Plus – VitaPost
ProJoint Plus is an advanced supplement, made to help relieve your joint pains. This formula is very powerful and it relieves you from joint pain originating from aging, injuries, and other factors.

Best Joint Pain Supplement: Joint N11 – Zenith Labs
Joint N-11 is an advanced joint health supplement that uses the ingredient Niacinamide which is a very effective form of vitamin B6 proven to combat joint inflammation in important ways.

Fast-Acting Joint Support: 1MD MoveMD
MoveMD is a joint supplement that is developed to help maintain healthy joints as well as alleviate joint pain. The combination is said to be helpful to both long-time athletes and people experiencing joint problems created by free radicals.

High Quality Joint & Muscle Health Formula: Turmeric Curcumin Plus
Turmeric Curcumin Plus is a dietary supplement that is vegan and is made of turmeric extracts. You may have heard of turmeric, as it is a spice that you might use every day. Turmeric, closely related to ginger, is a plant that is used in Asian cooking and health practices.

Best Joint Support Product: Turmeric Complex – Primal Harvest
Primal Harvest Turmeric Complex is an all-natural supplement that claims to support joint health, inflammatory response, healthy cholesterol levels, heart health, skin radiance, and brain health.

Best Pain Relief Supplement: Relief Factor
Relief Factor is a product specifically designed to reduce inflammation, which can be a cause of muscle and joint pain. This supplement has a combination of high-quality ingredients that claim to reduce discomfort associated with inflammation, including mild to moderate pain.
Best Supplements for Joint Pain: Our Top Picks
- Projoint Plus – Joint Support with Natural Glucosamine
- Heal-N-Soothe – Joint Health Support with Proteolytic Enzymes
- Relief Factor – Best Alternative of Pain Medication
- Joint N-11 – Advanced Joint Health Supplement
- 1MD MoveMD – Quick Result Joint Support
- Primal Harvest Turmeric Complex – All-Rounder Joint Support
- Turmeric Curcumin Plus – The Natural Super-Spice Supplement
- Arthrozene – Natural Joint Pain Reliever
- Replenex – Dietary Joint Pain Supplement
- Genacol – GMP Certified Joint Enhancer
- Instaflex – Advanced Joint Support supplement
Projoint Plus
- Price: $33.33 = OFFER PRICE –$29.95 (27% OFF)
- Key ingredients: Turmeric, Bromelain, Bromelain, Methionine, Boswellia extract, Glucosamine Sulfate, Quercetin, Chrondroitin Sulfate
- Recommended Uses For Product: Supports Healthy Cognitive Function, Supports Muscle and Joint Health, Helps Support a Healthy Immune System, Supports Cartilage Health, Supports Joint Health, Supports Natural Joint Mobility,
- Item Form: Capsules
- Volume: 60 Capsules
- Rating: 4.8/5.0
ProJoint Plus, a professional fusion of herbal extracts, is designed to enhance joint health. The 1500 mg of glucosamine sulphate in ProJoint Plus can help you keep your healthy joints in good shape. Another essential component of ProJoint Plus is chondroitin sulphate, which is naturally present in the extracellular matrix of your skin, cartilage, ligaments, bones, and tendons.
Customer Review:
“I had excruciating knee joint pain, but it has greatly lessened after taking ProJoint Plus for a month. I’m not sure which factor—time or the supplement—should be given the most credit for my relief, but I plan to keep using ProJoint Plus in the near future. Marvin Lee Pless
Heal-N-Soothe
- Price: $49.95 = OFFER PRICE – $39.95 (22% OFF)
- Key ingredients:
Devil’s Claw Root Extract, Boswellia Extract, Citrus Bioflavonoids Complex, Ginger Root Extract, Yucca Roo, Turmeric Rhizome, Alpha-Lipoic Acid - Recommended Uses For Product: Supports Joint Health, Comfort and Flexibility, Support a Healthy Immune System, Better Than Ordinary Turmeric Curcumin Supplements
- Item Form: Capsules
- Volume: 60 Capsules
- Rating: 4.4/5.0
Heal N Soothe’s all-natural ingredients include up to 12 different original essences and systematic proteins can potentially be used as an alternative to a joint pain relief supplement that has special qualities like anti-inflammatory and many others that are crucial in preventing or treating specific disorders in your body.
Customer Review:
“I had excruciating knee joint pain, but it has greatly lessened after taking ProJoint Plus for a month. I’m not sure which factor—time or the supplement—should be given the most credit for my relief, but I plan to keep using ProJoint Plus in the near future. Marvin Lee Pless
Relief Factor
- Price: $29.95 = OFFER PRICE – $19.95 (41% OFF)
- Key ingredients: Fish Oil Omega 3, Turmeric, Icariin & Resveratrole
- Recommended Uses For Product: Supports Healthy Cognitive Function, Supports Muscle and Joint Health, Helps Support a Healthy Immune System, Supports Cartilage Health, Supports Joint Health, Supports Natural Joint Mobility,
- Item Form: Capsules
- Volume: 60 Capsules
- Rating: 4.5/5.0
Relief Factor is a product specifically designed to reduce inflammation, which can be a cause of muscle and joint pain. This supplement has a combination of high-quality ingredients that claim to reduce discomfort associated with inflammation, including mild to moderate pain. Relief Factor may alleviate joint pain by reducing inflammation through the use of natural anti-inflammatory and antioxidant compounds.
Customer Review:
““If your knees hurt bad enough – which mine were – you’ll try just about anything…After four days, I thought ‘My knees aren’t hurting!’ I’ve been taking it ever since.” Dale B.
Joint N-11
- Price: $79.95 = OFFER PRICE – $49.00 (46% OFF)
- Key ingredients: NIACINAMIDE, BASIL LEAF POWDER, ROSEMARY, BIOPERINE, SOY LECITHIN, Glucosamine Sulfate, Quercetin, Turmeric
- Recommended Uses For Product: Supports Healthy Cognitive Function, Supports Muscle and Joint Health, Helps Support a Healthy Immune System, Supports Cartilage Health, Supports Joint Health, Supports Natural Joint Mobility,
- Item Form: Capsules
- Volume: 60 Capsules
- Rating: 4.9/5.0
Joint N-11 is an advanced joint health supplement that uses the ingredient Niacinamide, a very effective form of vitamin B6 proven to combat joint inflammation in essential ways.
Customer Review:
Best Joint Supplement Ever
A friend told me about this joint product, and I will be forever grateful. A few weeks later, my shoulder and back feel better than they have in years. I went golfing the other day and had no trouble with mobility – and my game was better than it has been in ages. I love this supplement! Rio
1MD MoveMD
- Price: $50.95 = OFFER PRICE – $40.99 (21% OFF)
- Key ingredients: ApresFlex, Zanthin, Type X.I.V Collagen, Type II Collagen, Hyaluronic Acid, Astaxanthin, Type X.I V Eggshell Membrane Collagen, Type II Chicken Collagen
- Recommended Uses For Product: Reduces Joint Discomfort in as Few as 5 Days*, Promote Joint Mobility & Flexibility, Helps Maintain Connective Tissue and Reduce Typical Oxidative Stress to Tissues For Less Stiffness & Soreness, Decrease Oxidative Stress,
- Item Form: Capsules
- Volume: 30 Capsules
- Rating: 4.8/5.0
MoveMD is a joint supplement that is developed to help maintain healthy joints as well as alleviate joint pain. It is to be helpful to both long-time athletes and people experiencing joint problems created by free radicals.
Customer Review:
“I had excruciating knee joint pain, but it has greatly lessened after taking ProJoint Plus for a month. I’m not sure which factor—time or the supplement—should be given the most credit for my relief, but I plan to keep using ProJoint Plus in the near future. Marvin Lee Pless
Primal Harvest Turmeric Complex
- Price: $33.33 = OFFER PRICE – $29.95 (10% OFF)
- Key ingredients: Turmeric, Bromelain, Bromelain, Methionine, Boswellia extract, Glucosamine Sulfate, Quercetin, Chrondroitin Sulfate
- Recommended Uses For Product: Supports Healthy Joints,Supports Inflammatory Response,Promotes Heart Health,Supports Brain Health,Promotes Radiant Skin, Helps Maintain Healthy Cholesterol Levels
- Item Form: Capsules
- Volume: 60 Capsules
- Rating: 4.8/5.0
Primal Harvest Turmeric Complex works as an active dietary supplement that is meant to improve overall health. In this Primal Harvest Turmeric Complex Review, You will discover and comprehend the benefits of this supplement to your joint health.
Customer Review:
I am so thankful to have found Primal Harvest!”
“I was hesitant about taking supplements but I gave it a try and the results were phenomenal! After 2 weeks of taking it, I noticed a remarkable difference in how I felt. I have also started adding Primal Flex to my regimen as well and that has really made a difference for me. – Patty D.
Arthrozene
- Price: $75.95 = OFFER PRICE – $64.33 (16% OFF)
- Key ingredients: Type II Collagen, Hyaluronic Acid, Glycosaminoglycans and ApresFlex Boswellia Serrata Extract.
- Recommended Uses For Product: Slow the breakdown of cartilage, Increase the production of joint fluid, Reduce soreness and discomfort, and Improve mobility and flexibility†.
- Item Form: Capsules
- Volume: 30 Capsules
- Rating: 4.8/5.0
Arthrozene is a natural joint supplement formulated for persons who suffer from joint discomfort on a regular basis. Most people experience inflammation, stiffness, and a lack of flexibility if left untreated, which can lead to a loss of mobility over time. This product is available for purchase on their website.
Customer Review:
“Well, I was surprised to actually feel some relief in my stiff knees. Now I can walk down stairs the real way. Not hobble one step at a time. Nice to find something that works as advertised for a change!” Kahren Rudbeck, Pillager, Minnesota
Replenex
- Price: $49.95 = OFFER PRICE – $37.33 (28% OFF)
- Key ingredients: Calcium, Glucosamine, Ginger Root Extract, Green Tea leaf extract, Enzymes (Bromelain and Papain)
- Recommended Uses For Product: reduce joint discomfort, inflammation, and stiffness, protect the cartilage from the damaging effects of free radicals, promotes strong bones.
- Item Form: Capsules
- Volume: 90 Capsules
- Rating: 3.5/5.0
Replenex is a natural joint pain relief supplement that addresses arthritic pain and swelling. It is intended to function in a variety of ways to help alleviate daily aches and pains and protect against additional cartilage deterioration.
Customer Review:
“Allergies reaction because of shrimp
“It’s very expensive, has shrimp, and I have allergies to anything that comes with shrimp. The seller never mentioned it. I can’t return it because it is open. It gave me a rash. Vilma Leiva
Genacol
- Price: $33.33 = OFFER PRICE –29.95 $ (10 % OFF)
- Key ingredients: Glucosamine hydrochloride, AminoLock Collagen, Gelatin, and Vegetable Magnesium Stearate.
- Recommended Uses For Product: Reliving Joint Discomfort, Antioxydents for joints, maintaining bone health, support joint health
- Item Form: Capsules
- Volume: 60 Capsules
- Rating: 4.8/5.0
Genacol is a natural joint supplement formulated for persons who suffer from joint discomfort regularly. Genacol is a line of health products to enhance joints’ functionality and health. Their solutions promote collagen formation while minimizing the damaging effects of inflammation on the body’s joints and connective tissue.
Customer Review:
“I used risky supplements for 15 years before switching to alternative therapy for my rheumatoid arthritis. After three days of using Genacol, which my chiropractor had prescribed, I feel like a brand-new person! When I jumped out of bed this morning, all I could say was Wow! Anybody with joint pain should use this product, in my opinion. Danciulescu
Omega XL
- Price: $69.95 = OFFER PRICE – $49.00 (35% OFF)
- Key ingredients: Perna Canaliculus PCSO-524 (patented oil extract), Monounsaturated Olive Oil, Vitamin E
- Recommended Uses For Product: Supports Healthy Cognitive Function, Supports Muscle and Joint Health, Helps Support a Healthy Immune System, Supports Cartilage Health, Supports Joint Health, Supports Natural Joint Mobility,
- Item Form: Capsules
- Volume: 60 Capsules
- Rating: 4.2/5.0
A nutritional supplement called Omega XL is intended to reduce inflammation and relieve joint discomfort. The consumer is given the information in a clear and concise manner, and the website also provides a video that explains how the product is created.
Customer Review:
Partially Effective
After using Omega XL for three months, I believe that some of the joint pain has decreased. It may be difficult to assess the efficacy on a personal level if the pain has been continuous for some time. Janice
Instaflex
- Price: $79.95 = OFFER PRICE – $69.99 (13% OFF)
- Key ingredients: BioPerine, UCII – 40mg, Resveratrol – 100mg, Turmeric – 200mg, Hyaluronic acid, ApresFlex Boswellia serrata extract
- Recommended Uses For Product: Supports Healthy Cognitive Function, Supports Muscle and Joint Health, Helps Support a Healthy Immune System, Supports Cartilage Health, Supports Joint Health, Supports Natural Joint Mobility,
- Item Form: Capsules
- Volume: 30 Capsules
- Rating: 4.0/5.0
A nutritional supplement Instaflexis intended to reduce inflammation and relieve joint discomfort. The consumer is given the information clearly and concisely, and the website also provides a video that explains how the product is created.
Customer Review:
I was afraid to try a supplement after receiving injections because my knees have been so bad, but I want to avoid knee replacements. I reasoned that because Instaflex was providing a free trial, I had nothing to lose. I’m grateful to you for these goods. I feel like my knees are brand new! It took me around 10 days to see a difference. Since then, I’ve been taking it every day, and I can now walk much more easily and without as much pain. It’s incredible. I don’t know if I’ll need replacements in the future, but by using this product, I can put that thought to rest. I have just tried this one non-prescription product. Janice
Benefits of Joint Supplements
Many popular joint supplements have a lot of benefits to offer people suffering from joint pain and inflammation. For example:
- They may diminish pain in the joints.
- These products could lessen joint inflammation.
- Many supplements are rich in antioxidants and strengthen the immune system.
- They contain a high number of anti-inflammatory agents.
- They are made of completely organic ingredients.
- Most products are only associated with mild side effects.
Points to Consider
- Compare the Cost: There is quite a wide range of prices when it comes to joint supplements. Just because a product is more expensive doesn’t mean it’s better. Do a comparison. Sometimes supplements with similar ingredients are priced very differently.
- Read the Ingredients: Have a careful look at the list of substances included in the supplement and do your homework. Research the ingredients on your own to check the quality of the product.
- Look for Allergens: If you have allergies, check the list carefully before you take the supplement. Check the label to see if there’s an allergen warning.
- Read the Label: For any product you’re going to take, it’s important to read the label carefully including the directions and warnings.
- Check with Your Doctor: Make an appointment with your physician before you take any new supplement, to get medical approval and to make sure that there are no contraindications with other medications.
Which are the Ingredients to Look for While Choosing best Supplements for Joint Pain?
There have been many recent studies, such as the GAIT study, which has examined a variety of natural joint support supplements. The clinical findings have shown there are several substances that alleviate inflammation and pain in arthritis sufferers.

Glucosamine
The glucosamine in your body helps keep up the health of your cartilage — the rubbery tissue that cushions bones at your joints. But as you get older, your levels of this compound begin to drop, which leads to the gradual breakdown of the joint.
People use glucosamine to treat the pain and inflammation of arthritis, especially when there is cartilage breakdown. An article in Seminars in Arthritis and Rheumatism looked the efficacy of this substance in treating arthritis.
“The most popular supplement to ease joint pain is glucosamine, which is also the most researched supplement for arthritis,” says Louis Malinow, MD, ASH Certified Hypertension Specialist, and Medical Advisory Board Member at Persona Nutrition, a personalized vitamin program.
It is the degeneration and loss of cartilage that is the defining feature of arthritis and that process causes inflammation. The supplement combination both protects the cartilage producing cells and has anti-inflammatory properties,” says Malinow, referencing the 2016 MOVES study.

Curcumin
This substance is rich in antioxidants called curcuminoids, of which the most potent is curcumin. Besides its healing properties, it strengthens the immune system. Turmeric is also high in anti-inflammatory agents which lessen pain and swelling. A study published in the Journal of Medicinal Food showed how effective turmeric is in treating the symptoms associated with joint arthritis.
“In numerous studies, individuals with joint stiffness and soreness reported improved joint function, a decrease in soreness, and an increase in ability to perform endurance exercise when taking curcumin supplements,” shares Joel Totoro, RD, and Director of Sports Science at Thorne.

Boswellia
Boswellia, or Indian frankincense, is a resin herbal extract from the Boswellia tree, which natural medicine practices have used for centuries. Its anti-inflammatory effects mean that it may help with inflammatory conditions, such as rheumatoid arthritis, inflammatory bowel disease, and asthma. An article in the Indian Journal of Pharmaceutical Sciences looked at the anti-inflammatory properties of Boswellia Serrata.
Boswellia extract has been used for many years in Eastern medicine and has grown in popularity for its beneficial inflammatory response property,” says Totoro.
“Boswellia has shown a proven ability to help maintain a healthy balance of the substances that control the body’s inflammatory response,” he continues, highlighting this review of Boswellia from last year that indicated that it can be effective in supporting the body’s response to stiffness, range of motion, and overall joint function in individuals who have long-term joint issues.

Omega-3
Omega-3 fatty acids are thought to help reduce the risk of heart disease. They have been used along with diet and exercise to help lower levels of a certain blood fat (triglyceride) and to raise levels of “good” cholesterol (HDL).
omega-3s, how we love you for your inflammation-fighting and heart-healthy superpowers. Liana Casusi, MD, a consultant for Oh So Spotless, shares an overview of omega-3s prowess:
“A study on athletes revealed that three grams of omega-3 supplementation daily helped reduce the development and severity of arthritis. During exercise, our bodies are subjected to transient inflammation, resulting in a release of chemical mediators called reactive oxygen species (ROS) which, if unregulated, may cause tissue damage,” she explains. “Omega-3 has been shown to reduce the damage done by these harmful substances by reducing joint inflammation and lessening pain, discomfort, and swelling.”

Vitamin D
Vitamin D is a nutrient you need for good health. It helps your body absorb calcium, one of the main building blocks for strong bones. Together with calcium, vitamin D helps protect you from developing osteoporosis, a disease that thins and weakens the bones and makes them more likely to break.
“Vitamin D is a hormone that maintains calcium homeostasis in the bones and regulates the immune system. It is synthesized in our skin with the help of ultraviolet irradiation or sunlight exposure,” shares Dr. Casusi.
“Vitamin D deficiency has been implicated in rheumatoid arthritis. Studies have shown that subsets of patients with the disease have decreased levels of vitamin D, and this is also linked to the severity of the disease,” she continues, explaining that people with low levels of vitamin D are, therefore more likely to develop arthritis and may have severe swelling, joint pains, and stiffness.
Other Ingredients in Joint Supplements
Each supplement has its own unique formula, but there are some ingredients that often overlap in these supplements. Here are some of the most commonly used active substances:
- Chondroitin – This is a substance that exists naturally in our connective tissue. It can repair damage to the tissue, which can improve arthritis symptoms. A study in the Journal of Bone and Joint Surgery showed the efficacy of chondroitin and glucosamine in treating osteoarthritis. However, very few if any studies have looked at chondroitin alone.
White Willow Bark – The bark of this tree contains a substance called salicin, which is very much like aspirin and has similar pain-relieving properties. According to Penn State Hershey Medical Center it’s also high in anti-inflammatory agents, which can further ease the pain and swelling that does along with arthritis.
Ginger – This is a flowering plant shoe root that has medicinal properties. A study in the Journal of Advanced Nursing found that the use of ginger compresses in the treatment of arthritis improved flexibility and mobility. This was largely due to the action of the anti-inflammatory properties.
Common Side Effects
Some of the substances used commonly in joint supplements have side effects, but they are mostly mild. According to the Mayo Clinic, glucosamine can cause nausea, heartburn, diarrhea, constipation, drowsiness, skin reactions, and headaches.
In addition, Boswellia Serrata can lead to diarrhea, nausea, stomach pain, and rash (source). Turmeric may also cause stomach upset, nausea, dizziness, and diarrhea (source).
If you should experience unpleasant side effects, stop taking the supplement immediately and see a doctor if you think it’s necessary.
Why Purchase a Joint Supplement?
Many people do not like to take prescription medication, especially pain pills which can be addictive. The option is taking an organic supplement is a good one if you like your products with all-natural ingredients.
In addition, many of the ingredients in these products have studies supporting their effectiveness in treating joint symptoms. A joint supplement could go a long way towards lessening the pain and inflammation that goes along with your arthritis. It could also support your general health and well-being.
What Does a Joint Supplement Do in My Body?
Most joint supplements are filled with anti-inflammatory agents, with greatly lessen the pain and swelling in the joints. They also tend to contain a lot of antioxidants, which can help heal the joints, cartilage, and connective tissue.
A research project published in Nutrition Journal found that knee arthritis can be very effectively treated with antioxidants.
Glucosamine and chondroitin are two ingredients that are very commonly included in joint supplements. These are substances that already exist in the body, in the fluid between the joints. They can fix damage to the cartilage, which is why they are often included as an ingredient. They can also lessen pain and inflammation in the joints.
How Do You Pick the Best Joint Supplement?
Supplements for joint pain are becoming a viable option for those suffering from joint pain. There are vast differences between joint relief products. It is a scientific fact that not all joint health supplements can achieve the same level of results or produce the same level of positive outcome that you are looking for.
The quality, efficacy, and potency of products within the industry vary from poor to outstanding.
How can one make the most informed decision?
The choices on the market are overwhelming, having evaluated hundreds of top-rated joint pain supplements we looked at the most current scientific research and established a list of criteria that make joint medicine outstanding.
We looked at essential ingredients needed to decrease joint pain, promote joint, cartilage, and tissue regeneration, the ability to prevent recurring damage, promote joint mobility and flexibility, and the quality of ingredients used in each product.
READ NEXT: Vitamins For Joint Pain – Recommended By Experts & Users
9 Sources
[2] Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700773/
[3] Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys https://www.sciencedirect.com/science/article/pii/S0049017215002899
[4] Understanding the Ingredients in Skin Care Products http://pennstatehershey.adam.com/content.aspx
[5] Boswellia Serrata, A Potential Antiinflammatory Agent: An Overview https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309643/
[6] Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003001/
[7] Ginger compress therapy for adults with osteoarthritis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984544/
[8] Glucosamine https://www.mayoclinic.org/drugs-supplements-glucosamine/art-20362874
[9] BOSWELLIA https://www.rxlist.com/consumer_boswellia_indian_frankincense/drugs-condition.htm
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